Spread Spectrum (SS) radio communications is on the verge of potentially explosive commercial development. A SS multiple accesses, such as CDMA, have been chosen for 3G wireless communications. Other current applications of SS techniques are in Wireless LAN and Satellite Navigation Systems. However, SS techniques will play important role also in future wireless applications, mainly combined with other technologies such as OFDM, MIMO and UWB. In this paper, after an overview on SS signaling and its advantages, some of the most important techniques based on SS signaling for current and future wireless applications are described. Particular relevance is given to DS- CDMA and hybrid CDMA-based multiple access schemes, such as TDMA-OFDM, OFDM-CDMA